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Chargers vs. 49ers prediction, odds and pick for NFL Week 10

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49ers Panthers Football

San Francisco 49ers place kicker Robbie Gould (9) lines up to attempt a field goal during an NFL football game against the Carolina Panthers, Sunday, Oct. 9, 2022, in Charlotte, N.C. (AP Photo/Brian Westerholt)

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The Los Angeles Chargers and San Francisco 49ers are scheduled to meet in the NFL at Levi's Stadium on Sunday. Kickoff is at 8:20 p.m. EST.

The 49ers are listed as betting favorites against the Chargers on 11/13/22, with the Over/Under for total points scored set at 45.

This Chargers-49ers betting analysis, which features game predictions and odds, is presented by BetMGM and powered by Dimers.com.

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Los Angeles Chargers vs. San Francisco 49ers

Key information

  • Date: Sunday, November 13, 2022
  • Time: 8:20 p.m. EST
  • Venue: Levi's Stadium

Odds and lines

  • Point spread: 49ers -7 (-105), Chargers +7 (-110)
  • Moneyline: 49ers -295, Chargers +260
  • Total: Over/Under 45 (-110/-110)

Odds and lines in this article are best available at time of publishing and subject to change.

Chargers vs. 49ers predictions

Dimers has simulated Sunday's Chargers-49ers NFL matchup 10,000 times using independent data and modeling to predict the most likely outcomes.

According to Dimers' predictive analytics model, the 49ers have a 74% chance of winning against the Chargers at Levi's Stadium.

Dimers also predicts that the bookies have got it right and both the Chargers and 49ers have a 50% chance of covering the spread.

The 45-point Over/Under has a 51% chance of going Over.

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Predictions and probabilities are correct at time of publishing but always subject to change.

Best bet for Chargers vs. 49ers

Our free computer pick for Chargers vs. 49ers on Sunday is 49ers moneyline (-295).

➡️ Bet now ⬅️ with BetMGM.

All betting content in this article is based on world-class simulations and hundreds of data points to serve you the best possible plays.

Chargers-49ers Week 10 player props

A common way to wager on LA Chargers vs. San Francisco without necessarily betting on the game's outcome is through player props.

The most likely first and anytime touchdown scorers for the Chargers and 49ers are listed below.

According to Dimers, San Francisco's Christian McCaffrey has the best chance of scoring the first touchdown in Chargers vs. 49ers.

Dimers gives McCaffrey a 17.2% chance of scoring the opening TD on Sunday. The 49ers RB has a 62.1% probability of scoring an anytime touchdown.

First touchdown scorer probabilities

Los Angeles Chargers

  • Austin Ekeler: 13.3% probability
  • Joshua Palmer: 6.7% probability
  • Gerald Everett: 5.4% probability
  • DeAndre Carter: 5.2% probability
  • Justin Herbert: 3.5% probability

San Francisco 49ers

  • Christian McCaffrey: 17.2% probability
  • Deebo Samuel: 8.3% probability
  • George Kittle: 7.0% probability
  • Brandon Aiyuk: 6.1% probability
  • Jimmy Garoppolo: 4.6% probability

Anytime touchdown scorer probabilities

Los Angeles Chargers

  • Austin Ekeler: 52.5% probability
  • Joshua Palmer: 30.7% probability
  • Gerald Everett: 25.7% probability
  • DeAndre Carter: 25.6% probability
  • Justin Herbert: 18.3% probability

San Francisco 49ers

  • Christian McCaffrey: 62.1% probability
  • Deebo Samuel: 35.6% probability
  • George Kittle: 30.3% probability
  • Brandon Aiyuk: 28.9% probability
  • Jimmy Garoppolo: 21.6% probability

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Chargers vs. 49ers score prediction

Dimers' predicted final score for LA Chargers vs. San Francisco at Levi's Stadium has the 49ers winning 26-19.

This prediction is based on both teams' average score after 10,000 game simulations.

The NFL Week 10 matchup between the Chargers and 49ers on Sunday is scheduled to start at 8:20 p.m. EST at Levi's Stadium.


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Dimers.com provides premium sports betting content to this site, including data-driven picks, analysis, and sportsbook promotions to help bettors get in on the action.

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