— Raiders receiver Davante Adams, formerly Rodgers' favorite target in Green Bay, needs 115 catches to become the first player to reach that mark in three consecutive seasons. Should Adams reel in at least 10 touchdown catches, he would be the fourth receiver with at least 10 touchdown receptions in at least six of his first nine seasons. The other three are in the Hall of Fame: Jerry Rice, Marvin Harrison and Randy Moss.
— If Buffalo's Josh Allen runs for five or more touchdowns this season, he would join Cam Newton, who currently is the only quarterback with at least five rushing touchdowns in five consecutive seasons.
— The Chargers' Keenan Allen is a 100-catch season away from joining Antonio Brown and Harrison as the only players with 100 receptions four seasons in a row.
— New England's Bill Belichick, who ranks third all-time with 321 total (regular season and postseason) victories, needs four more to pass George Halas on that list. Belichick needs 10 wins to join Halas (318) and Miami's Don Shula (328) as the only coaches with at least 300 regular-season victories.
— Should Brady throw for 5,000 yards, he would join Drew Brees as the only players in NFL history to record consecutive 5,000-yard seasons.
— If he throws for at least 4,338 yards, Cincinnati's Joe Burrow would surpass Jameis Winston (11,636) for third-most yards passing in his first three seasons. The leaders on that list both played in Indianapolis: Manning (12,287) and Andrew Luck (12,957).
— The Bengals Ja'Marr Chase needs 1,562 yards receiving to pass Minnesota's Justin Jefferson (3,016) for the most yards by a receiver in his first two seasons.
— Herbert needs 30 touchdown passes to surpass Dan Marino (98) for the most by a player through his first three seasons.
— Should he make at least eight interceptions, Chargers cornerback J.C. Jackson would become the first player with at least eight picks in three consecutive seasons.
— Chargers running back Austin Ekeler needs just one touchdown reception to top James White (24) for the most touchdown catches by a running back in his first six seasons since the AFL-NFL merger in 1970.
— If Donald were to collect at least 12 sacks, he would be the fourth player since 1982 — when sacks became an official stat — with 110 sacks in his first nine seasons. The others are Jared Allen and DeMarcus Ware, each with 117, and Reggie White (137).
— The Rams' Cooper Kupp has the chance to become the fourth player since 1970 to lead or tie the league in touchdown receptions in back-to-back seasons. The receivers who accomplished that are Jerry Rice, Terrell Owens and Larry Fitzgerald.
— Green Bay's Rodgers can become the first player to win three consecutive most valuable player awards and can tie Manning (five) for the most all time. Also, Rodgers can become the first player with at least 40 touchdown passes in four different seasons.
— The Rams' Matthew Stafford needs 4,000 yards passing to become the seventh player with 10 such seasons. He would join Manning, Brady, Brees, Rivers, Rodgers and Matt Ryan.